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Level A Internal Tagging: The In vitro blocking tag is added to Level A studies to indicate further molecular mechanism support (e.g., receptor/pathway verification at the cellular level), forming a dual loop of in vivo function + in vitro mechanism. This tag is for result presentation and interpretative discussion only and does not alter the primary A/B/C classification

doi: 10.1073/pnas.2509312122

Oxidized glutathione is regenerated to GSH through glutathione reductase in an NADPH-dependent process, enabling continuous antioxidant activity